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Reliable Identification of SARS-CoV-2-Specific T-Cell Responses
Explore T-Cell Immunity in COVID-19
A deeper understanding of virus-specific T-cell responses to COVID-19 is needed to evaluate vaccine candidates, explore long-term immunity, predict patients at risk, and even prepare for the next pandemic.
Dextramer® technology can help you monitor and characterize SARS-CoV-2- specific CD4+ and CD8+ T cells in blood, without missing rare or low-affinity cells, in an easy and reproducible way.
Learn More about T Cells and COVID-19
Frequencies of SARS-CoV-2-specific CD8+ T cells detected in PBMCs at different time points from a vaccinated convalescent donor with a SARS-CoV-2 MHC I Panel of Non-Spike Epitopes.
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SARS-CoV-2 Dextramer® Reagents
All SARS-CoV-2 Dextramer® reagents are available for detection of antigen-specific T cells by in-situ staining, flow cytometry, NGS or single-cell multi-omics. All specificities listed below are also available as MHC Monomers.
MHC I or MHC II Dextramer® - for identification of antigen-specific T cells by flow cytometry
dCODE Dextramer® (HiT) - for bulk analysis of antigen-specific T cells by PCR and NGS
dCODE Dextramer® (10x) - for single-cell multi-omic analysis of antigen-specific T cells to combine information on TCR recognition, TCR sequencing, and gene expression using 10x Chromium Single Cell analysis.
dCODE Dextramer® (RiO) - for single-cell multi-omic analysis of antigen-specific T cells to combine information on TCR recognition, TCR sequencing, and gene expression using BD RhapsodyTM Single-Cell Analysis.
MHC I or MHC II Monomers – for flexible investigation of antigen-specific T cells
MHC Dextramer® Reagents
dCODE Dextramer® Reagents
SARS-CoV-2 Dextramer® Panels
We provide SARS-CoV-2 Dextramer® reagents in panels targeting Spike or Non-Spike epitopes, each with a selection of validated T-cell epitopes.
Alternatively, select your own custom panel based on our selection of SARS-CoV-2 Dextramer® reagents, or order individual Dextramer® reagents.
The immunodominant SARS-CoV-2 specific T-cell epitopes listed below are known to be present in large populations, based on publications and in-house knowledge, enabling researchers to monitor T-cell immunity across COVID-19 variants.
SARS-CoV-2 MHC I Panel of Spike Epitopes
|
Allele |
Peptide |
Antigen |
Delta |
Omicron BA 2.12.1 |
Omicron BA.4 |
Omicron BA. 5 |
|
A*0101 |
LTDEMIAQY |
S |
|
|
|
|
|
A*0101 |
WTAGAAAYY |
S |
|
|
|
|
|
A*0201 |
YLQPRTFLL |
S |
|
|
|
|
|
A*0201 |
FIAGLIAIV |
S |
|
|
|
|
|
A*0301 |
KCYGVSPTK |
S |
|
|
|
|
|
A*0301 |
GVYFASTEK |
S |
|
GVYFASIEK |
|
|
|
A*1101 |
RLFRKSNLK |
S |
|
|
|
|
|
A*1101 |
KCYGVSPTK |
S |
|
|
|
|
|
A*1101 |
GVYFASTEK |
S |
|
GVYFASIEK |
|
|
|
A*2402 |
QYIKWPWYI |
S |
|
|
|
|
|
A*2402 |
NYNYLYRLF |
S |
NYNYRYRLF |
|
NYNYRYRLF |
NYNYRYRLF |
|
B*0702 |
SPRRARSVA |
S |
SRRRARSVA |
SHRRARSVA |
SHRRARSVA |
SHRRARSVA |
|
B*0702 |
APHGVVFL |
S |
|
|
|
|
|
B*3501 |
QPTESIVRF |
S |
|
|
|
|
|
B*3501 |
LPFNDGVYF |
S |
|
|
|
|
|
B*3501 |
IPFAMQMAY |
S |
|
|
|
|
Spike-specific CD8+ T-cell epitopes in the SARS-CoV-2 Dextramer® Panels, and the conservation of these epitopes across the SARS-CoV-2 Delta (B.1.617.2) and Omicron (BA 2.12.1, BA. 4, BA. 5) variants. All epitopes are conserved in the reference strain (NC_045512). Mutations in the epitope are shown in red. Learn more in this Application Note.
SARS-CoV-2 MHC I Panel of Non-Spike Epitopes
|
Allele |
Peptide |
Antigen |
Delta |
Omicron |
Omicron BA.4 |
Omicron BA. 5 |
|
A*0201 |
LLLDRLNQL |
N |
|
|
|
|
|
A*0301 |
KTFPPTEPK |
N |
|
|
|
|
|
A*1101 |
KTFPPTEPK |
N |
|
|
|
|
|
B*0702 |
SPRWYFYYL |
N |
|
|
|
|
|
A*0101 |
FTSDYYQLY |
ORF3a |
|
|
|
|
|
A*0201 |
LLYDANYFL |
ORF3a |
|
|
|
|
|
A*2402 |
VYFLQSINF |
ORF3a |
|
|
|
|
|
A*0101 |
TTDPSFLGRY |
ORF1ab |
TTDLSFLGRY |
|
|
|
|
A*0201 |
ALWEIQQVV |
ORF1ab |
|
|
|
|
|
A*0301 |
VVYRGTTTYK |
ORF1ab |
|
|
|
|
|
A*1101 |
ASMPTTIAK |
ORF1ab |
|
|
|
|
|
A*2402 |
VYIGDPAQL |
ORF1ab |
|
|
|
|
|
B*0702 |
IPRRNVATL |
ORF1ab |
|
|
|
|
Non-Spike-specific CD8+ T-cell epitopes in the SARS-CoV-2 Dextramer® Panels, and the conservation of these epitopes across the SARS-CoV-2 Delta (B.1.617.2), and Omicron (BA 2.12.1, BA. 4, BA. 5) variants. Green = no mutations in epitope, Red = mutations in epitope. All epitopes are conserved in the reference strain (NC_045512). Mutations in the epitope are shown in red. Learn more in this Application Note.
Order your SARS-CoV-2 Panels
Please contact our application specialist if you would like to discuss your research.
Please include information on:
- Your preferred epitope(s) and alleles for MHC Dextramer®, dCODE Dextramer®, or MHC Monomer
- Your preferred reagent format: MHC Dextramer® or dCODE Dextramer®
- Your preferred dye (for MHC Dextramer®): PE, APC, FITC, or None
- Test size:
o MHC Dextramer®, select between 50 or 150 tests
o dCODE Dextramer®, select between 25, 50, or 150 tests
o MHC Monomers select between 20 µg (~50 tests), 100 µg (~250 tests), or 200 µg (~500 tests)
Published Human COVID-19 T-Cell Epitopes
Download the list of epitopes in COVID-19 infected or vaccinated individuals
Published Mouse COVID-19 T-Cell Epitopes
Download the list of epitopes in COVID-19 infected genetically modified mice.
Want to Hear More About Our SARS-CoV-2 Solutions?
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