Immune Monitoring in Infectious Diseases

Detect Virus-Specific T-cell Immunity

Activation of T cells specific for persistent and acute viral infection is central in human anti-viral immunity. Immune monitoring of virus-specific T cells can provide knowledge about the virus-specific immune status and the risk of severe disease upon infection in immune-compromised patients. Understanding virus-specific T-cell responses is also important for defining correlates of protective immunity and identifying effective vaccine antigens.

Dextramer® reagents can detect, quantify, and isolate virus-specific T cells subsets, using flow cytometry. Check out the different virus-specific Dextramer products:

COVID-19 Specific Dextramer® Products

A deeper understanding of COVID-19 immunity is needed to explore vaccine responses, long-term immunity, predict patients at risk, and even prepare ourselves for a possible new pandemic in the future.

Our unique immune monitoring tools can help you unravel the SARS-CoV-2 specific T-cell immunity in an easy and reproducible way.

We provide four SARS-CoV-2 Packages, each with a curated collection of SARS-CoV-2-specific Dextramer® reagents displaying validated T-cell epitopes. Select the one most suitable for your research:

  • SARS-CoV-2 Spike Package
  • SARS-CoV-2 A*0201 Package
  • SARS-CoV-2 Multi Allele Package
  • SARS-CoV-2 Custom Package

For more details, please read here or contact us

Virus Dextramer® Collection 1

Opportunistic viruses can cause severe diseases in immune-compromised patients. Measuring the virus immune status is an important tool to check the risk of infection in immune-compromised patients.

The Virus Dextramer Collection 1 consists of Dextramer reagents, displaying immunodominant, well-characterized epitopes derived from four general and opportunistic viruses: Cytomegalovirus (CMV), Epstein-Barr virus (EBV), Influenza, and BK virus and a negative control Dextramer.

Cat. No. RX03

Virus-specific Dextramer®
MHC
Allele/Peptide

Virus Tests* 
HLA-A*0201 / NLVPMVATV CMV 50 tests
HLA-A*0201 / GLCTLVAML EBV 50 tests
HLA-A*0201 / GILGFVFTL Influenza 50 tests
HLA-A*0201 / LLMWEAVTV BK virus 50 tests
HLA-A*0201 / Negative Control  - 50 tests

* One test is defined as 10 µl MHC Dextramer reagent sufficient to stain up to 1-3 x 10^6 lymphoid cells or 1-3 x 10^5 clonal antigen-specific T cells.

Virus Dextramer® Collection 1 is for research use only.

CMV Dextramer® Package

CMV infection and disease pose a major risk in immunosuppressed patients. Reactivation of CMV is a frequently occurring complication and can contribute to morbidity and mortality if not controlled. CMV-specific CD8+ T cells are considered the main factor in successful management of CMV infection. In transplant patients a low number of CMV-specific CD8+ T cells are predictive for development of CMV-related complications.​

The CMV Dextramer Package consists of Dextramer reagents, displaying immunodominant, well-characterized epitopes derived from CMV-specific antigens and a negative control Dextramer. The CMV Dextramer Package is for research use only. For In Vitro Diagnostics (IVD) use check out the Dextramer® CMV Kit.

Cat. No. CMV-PACK.02

CMV-specific Dextramer®
MHC Allele/Peptide
Antigen Tests*
HLA-A*0101 / VTEHDTLLY pp50 50 tests
HLA-A*0201 / NLVPMVATV pp65 2 x 50 tests
HLA-A*0301 / KLGGALQAK IE-1 50 tests
HLA-A*2402 / QYDPVAALF pp65 50 tests
HLA-B*0702 / RPHERNGFTVL pp65 50 tests
HLA-B*0702 / TPRVTGGGAM pp65 50 tests
HLA-B*0801 / ELRRKMMYM pp65 50 tests
HLA-B*3501 / IPSINVHHY pp65 50 tests
General / Negative Control  -  3 x 50 tests

* One test is defined as 10 µl MHC Dextramer reagent sufficient to stain up to 1-3 x 10^6 lymphoid cells or 1-3 x 10^5 clonal antigen-specific T cells.

EBV Dextramer® Package 1

EBV is a persistent virus that infects 90% of the human population. Primary infection may cause acute infectious mononucleosis, and persistent infection may be associated with the development of several malignancies. T cells play a critical role in controlling both the primary and persistent phases of infection.

The package consists of Dextramer® reagents displaying immunodominant, well-characterized epitopes derived from EBV-associated antigens and a negative control Dextramer.

Cat. No. RX05

EBV-specific Dextramer®
MHC Allele/Peptide

Antigen Tests*
HLA-A*0201 / GLCTLVAML BMLF-1 50 tests
HLA-B*3501 / HPVGEADYFEY EBNA-1 50 tests
HLA-B*0702 / RPPIFIRRL EBNA-3A 50 tests
HLA-B*0801 / FLRGRAYGL EBNA-3A 50 tests
General / Negative Control  - 50 tests

* One test is defined as 10 µl MHC Dextramer reagent sufficient to stain up to 1-3 x 10^6 lymphoid cells or 1-3 x 10^5 clonal antigen-specific T cells.

EBV Dextramer® Package 1 is for research use only.

How to Order Virus-Specific Dextramer® Products

Send an e-mail to ordering@immudex.com specifying

  • Cat. no. of collection or package
  • Fluorophore (PE, APC, or FITC) or no Fluorophore (None)
Product Regulatory Status Size Cat.No Price (EUR) Price (USD)
COVID-19 Specific Dextramer® Products RUO  

 

Contact us Contact us
Virus Dextramer® Collection 1 RUO 5 x 50 tests

RX03

3.679 4,299
CMV Dextramer® Package RUO 9 x 50 tests

CMV-PACK.02

5.699 6,199
EBV Dextramer® Package 1 RUO 4 x 50 tests RX05
2.999
3,499

Related Products

Dextramer® reagents included in the collection and packages are available as single reagents.

Additional virus-specific Dextramer reagents not included in the collections are available.

  • Find them here by searching for either "Virus", "CMV", "EBV", or "Influenza" in the category field. Please remember to press clear filter between each search
  • Customer-defined cancer-specific Dextramer reagents with your choice of MHC-peptide combination are easily made with MHC alleles from our catalog and with peptides that form stable complexes with the MHC molecule

Our Technology

All our products are based on the following technologies:

Dextramer®Technology

dCODE® Technology

Klickmer™ Technology

Contact Us

Ordering
Email: ordering@immudex.com
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Fax: +45 77 31 15 09
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Technical Support
Email: customer@immudex.com