Deciphering Immune Cell Activity in Autoimmune Conditions
Autoreactive T cells are key mediators of abnormal immune responses against a patient’s own healthy cells – a situation that manifests itself in a broad spectrum of conditions from celiac disease to rheumatoid arthritis, multiple sclerosis, and diabetes mellitus type 1.
Both CD8+ and CD4+ T cells have long been implicated in autoimmunity. Given their role in recruiting and coordinating other immune cells, CD4+ T cells are particularly important for immune monitoring.
A New Perspective for Chronic Diseases
With documented increases in incidence, diabetes and celiac disease are significant burdens on global healthcare. Interrogating CD8+ and CD4+ T cells by flow cytometry allows clinicians to identify and enumerate antigen-specific populations to improve diagnosis, treatment, and ultimately prognoses for patients.
With boosted avidity and an extensive menu of allele-peptide combinations, MHC class I and MHC class II Dextramer® reagents are effective tools to monitor autoreactive CD8+ and CD4+ T cells.
Capture Signatures of Autoimmunity with Dextramer® Reagents
Discover a curated selection of our autoimmune-specific reagents
MHC I Dextramer® reagents to detect antigen-specific CD8+ T cells
|
Cat. No. |
Allele |
Peptide |
Antigen |
Category/Disease |
|
WB2744 |
HLA-A*0201 |
YTCPLCRAPV |
SAA |
Autoimmune |
|
WB3405 |
HLA-A*0201 |
VMNILLQYVV |
GAD65 |
Diabetes |
|
WB3402 |
HLA-A*0201 |
YAYDGKDYIA |
HLA-A2 |
Diabetes |
|
WB3406 |
HLA-A*0201 |
MVWESGCTV |
IA-2 |
Diabetes |
|
WB3560 |
HLA-A*0201 |
VIVMLTPLV |
IA-2 |
Diabetes |
|
WB3448 |
HLA-A*0201 |
LNIDLLWSV |
IGRP |
Diabetes |
|
WB3329 |
HLA-A*0201 |
VLFGLGFAI |
IGRP |
Diabetes |
|
WB3404 |
HLA-A*0201 |
ALWGPDPAAA |
Insulin |
Diabetes |
|
WB3403 |
HLA-A*0201 |
HLVEALYLV |
Insulin |
Diabetes |
|
WB3481 |
HLA-A*0201 |
FLLSLFSLWL |
ZnT-8 |
Diabetes |
|
WB3482 |
HLA-A*0201 |
HIAGSLAVV |
ZnT-8 |
Diabetes |
|
WB3483 |
HLA-A*0201 |
ILKDFSILL |
ZnT-8 |
Diabetes |
|
WB3484 |
HLA-A*0201 |
VVTGVLVYL |
ZnT-8 |
Diabetes |
To order your MHC I reagents, visit our MHC I Dextramer® page
MHC II Dextramer® reagents to detect antigen-specific CD4+ T cells
|
Cat. No. |
Allele |
Peptide |
Antigen |
Category/Disease |
|
FI10187 |
HLA-DQ2.5 |
QLQPFPQPELPY |
α-I, Gliadin |
Celiac Disease |
|
FI10188 |
HLA-DQ2.5 |
GMATPLLMQALPMGAL |
CLIP2 |
Endogenous Ag |
|
FB10012 |
DRB1*0401 |
GAGSLQPLALEGSLQKRG |
Proinsulin |
Diabetes |
|
FB10013 |
DRB1*0401 |
IAFTSEHSHFSLK |
GAD65 |
Diabetes |
|
FB10014 |
DRB1*0401 |
NFIRMVISNPAAT |
GAD65 |
Diabetes |
| FB10002 | DRB1*0401 | PVSKMRMATPLLMQA | CLIP | Endogenous Ag |
| FC10049 | DRB1*1501 | ISMYTFSTMKANVGMGR | Large T antigen | Progressive multifocal leukoencephalopathy/JC Polyomavirus |
| FC10055 | DRB1*1501 | PVDLHAFLSQAVFS | Large T antigen | Progressive multifocal leukoencephalopathy/JC Polyomavirus |
| FC10063 | DRB1*1501 | ENPVVHFFKNIVTPR | Myelin basic protein | Multiple sclerosis |
| FC10113 | DRB1*1501 | RVLGLVLLRGENLVS | SNRBP | Cancer - Glioblastoma |
| FC10125 | DRB1*1501 | SLLKKYLTKEVFDKL | Arginine kinase Lit v 2 | Shrimp allergy (Penaeus vannamei) |
| FC10144 | DRB1*1501 | KGIFVIQSESLKKCI | Phospholipase A2 Receptor 1 | Idiopathic Membranous Nephropathy |
| FC10145 | DRB1*1501 | NANMTWYAAIKTCLM | Phospholipase A2 Receptor 1 | Idiopathic Membranous Nephropathy |
| FC10158 | DRB1*1501 | ENPVVHFFKNIVTPRTP | Myelin basic protein | Multiple sclerosis |
| FC10159 | DRB1*1501 | MEVGWYRPPFSRVVHLYRNGK | Myelin oligodendrocyte glycoprotein | Multiple sclerosis |