Identification and Characterization of Human Antigen-Specific T Cells Using DNA-Barcoded pHLA Multimers
Webinar Recording
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The Schober Lab is dedicated to unraveling the molecular orchestration of T-cell responses. By synergizing DNA-barcoded multimer technology with single-cell sequencing, the team provides a multidimensional view of T-cell function and the structural nuances of TCR-pMHC interactions.
Key Learning Objectives:
- Learn how DNA-barcoded pHLA multimers enable the simultaneous screening of bigger panel of antigen specificities in a single sample.
- Understand the workflow for combining DNA-barcoded pHLA multimers with single-cell multi-omics to link TCR sequences with cellular phenotypes.
- Explore how these high-throughput techniques are being used to characterize T-cell responses in human health and disease.
- Discover how DNA-barcoding improves the resolution and sensitivity of antigen-specific T-cell detection.
Speakers:
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Kilian Schober, MD | Heisenberg-Professor for T-Cell Immunology, FAU Erlangen-Nürnberg
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Rasmus Friis, PhD | Global Product Manager, Immudex