MHC I Dextramer® – Identify Antigen-Specific CD8+ T Cells

Capture the Complete Diversity of T Cells

MHC I binds and presents antigens from the cell cytosol to activate antigen-specific CD8+ T cells. This antigen-specific immune response is a key process in cancer, autoimmune disease, transplantation, infectious disease, and allergy. Thus, examining the full repertoire of CD8+ T cells, including those with low antigen affinity, is essential.

With an optimized number of MHC-peptide complexes and a choice of fluorophores (PE, APC, FITC, or none), MHC I Dextramer® reagents boost analysis sensitivity in flow cytometry beyond that achieved by other technologies.

READ MORE DETAILS IN OUR FAQs

GMP Dextramer® Reagents

Reagents in accordance with ISO 13485 and 21 CFR 820

Dextramer® Technology

The backbone of precision immune monitoring

MHC I Dextramer® Flyer

Find more information about MHC Dextramer® 

MHC I Dextramer® Protocol

Download the staining protocol for single and multiple reagents.

MHC I Dextramer® detects low-affinity antigen-specific CD8+ T cells invisible to the corresponding tetramer (Dolton et al. 2014).

No Compromises in Performance

MHC I Dextramer® reagents are designed to meet strict quality and performance criteria, ensuring highly reliable research insights.

  • Get the full picture of CD8+ T-cell responses, even the low-affinity ones.
  • Ensure consistent, reproducible, and comparable results
  • Expand the limits of your research
  • Secure flexibility in your experiments

 

Discover Dextramer® Controls

Order MHC I Dextramer®

You can order MHC I Dextramer® reagents in one of three ways:

  1. Use the table below to find and order your MHC I Dextramer® reagent online
  2. If you can’t find the reagent to meet your research needs, create a custom reagent using our custom tool at the bottom of the page
  3. Alternatively, send an e-mail to ordering@immudex.com specifying: 
  • Catalog number or desired MHC allele-peptide combination:
        - Calculate the predicted MHC-peptide affinity using our prediction tool
        - Consult our lists of available MHC alleles
  • Fluorophore (PE, APC, FITC, or none)
  • Test size (50,150, 500, 1000 tests). One test is 10 µl reagent and sufficient to stain 1–3 x 106 lymphoid cells or 1–3 x 105 clonal antigen-specific T cells.

Immudex has updated the catalog numbers. To learn more about it, please consult the document here

T-Cell Epitopes for the Most Commonly Used Cancer Models Are Also Available

Follow the ordering instructions to get the right MHC I reagents for your research

 

Mouse Model

Antigen

Allele

Peptide

MC38

Rpl18

H-2 Kb

KILTFDRL

Adpgk

H-2 Db

ASMTNMELM

Cpne1

H-2 Db

SSPYSLHYL

Irgq

H-2 Db

AALLNSAVL

Reps1

H-2 Db

AQLANDVVL

B16

TRP2

H-2 Kb

SVYDFFVWL

Gp100

H-2 Db

KVPRNQDWL

SIY

H-2 Kb

SIYRYYGL

CT26

AH1

H-2 Ld

SPSYVYHQF

B16-OVA

OVA

H2 Kb

SIINFEKL

a

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