Reagents in accordance with ISO 13485 and 21 CFR 820
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MHC I Dextramer® – Identify Antigen-Specific CD8+ T Cells
Capture the Complete Diversity of T Cells
MHC I binds and presents antigens from the cell cytosol to activate antigen-specific CD8+ T cells. This antigen-specific immune response is a key process in cancer, autoimmune disease, transplantation, infectious disease, and allergy. Thus, examining the full repertoire of CD8+ T cells, including those with low antigen affinity, is essential.
With an optimized number of MHC-peptide complexes and a choice of fluorophores (PE, APC, FITC, or none), MHC I Dextramer® reagents boost analysis sensitivity in flow cytometry beyond that achieved by other technologies.
READ MORE DETAILS IN OUR FAQs
MHC I Dextramer® detects low-affinity antigen-specific CD8+ T cells invisible to the corresponding tetramer (Dolton et al. 2014).
No Compromises in Performance
MHC I Dextramer® reagents are designed to meet strict quality and performance criteria, ensuring highly reliable research insights.
- Get the full picture of CD8+ T-cell responses, even the low-affinity ones.
- Ensure consistent, reproducible, and comparable results
- Expand the limits of your research
- Secure flexibility in your experiments
Discover Dextramer® Controls
Order MHC I Dextramer®
You can order MHC I Dextramer® reagents in one of three ways:
- Use the table below to find and order your MHC I Dextramer® reagent online
- If you can’t find the reagent to meet your research needs, create a custom reagent using our custom tool at the bottom of the page
- Alternatively, send an e-mail to ordering@immudex.com specifying:
- Catalog number or desired MHC allele-peptide combination:
- Calculate the predicted MHC-peptide affinity using our prediction tool
- Consult our lists of available MHC alleles - Fluorophore (PE, APC, FITC, or none)
- Test size (50,150, 500, 1000 tests). One test is 10 µl reagent and sufficient to stain 1–3 x 106 lymphoid cells or 1–3 x 105 clonal antigen-specific T cells.
Immudex has updated the catalog numbers. To learn more about it, please consult the document here
T-Cell Epitopes for the Most Commonly Used Cancer Models Are Also Available
Follow the ordering instructions to get the right MHC I reagents for your research
|
Mouse Model |
Antigen |
Allele |
Peptide |
|
MC38 |
Rpl18 |
H-2 Kb |
KILTFDRL |
|
Adpgk |
H-2 Db |
ASMTNMELM |
|
|
Cpne1 |
H-2 Db |
SSPYSLHYL |
|
|
Irgq |
H-2 Db |
AALLNSAVL |
|
|
Reps1 |
H-2 Db |
AQLANDVVL |
|
|
B16 |
TRP2 |
H-2 Kb |
SVYDFFVWL |
|
Gp100 |
H-2 Db |
KVPRNQDWL |
|
|
SIY |
H-2 Kb |
SIYRYYGL |
|
|
CT26 |
AH1 |
H-2 Ld |
SPSYVYHQF |
|
EG.7-OVA |
OVA |
H2 Kb |
SIINFEKL |
|
MC38-OVA |
OVA |
H2 Kb |
SIINFEKL |
|
B16-OVA |
OVA |
H2 Kb |
SIINFEKL |