All our products are based on the following technologies:
MHC I Dextramer®
Identify Antigen-specific CD8+ T Cells
Antigen-specific CD8+ T cells play an important role in the immune response of autoimmune disease, cancer, transplantation, infectious disease, and allergy.
MHC I Dextramer® reagents can identify antigen-specific CD8+ T cell subsets by flow cytometry.
MHC I Dextramer reagents consist of a protein-stabilizing dextran backbone, an optimized number of MHC-peptide complexes, and fluorophores (PE, APC, or FITC) no fluorophore (None).
Immudex manufactures MHC I Dextramer reagents as listed in the table below. Customized reagents are easily made with MHC alleles from our catalog and with peptides that form stable complexes with the MHC molecule.
MHC I Dextramer reagents can identify low-affinity antigen-specific CD8+ T cells not detectable with the corresponding Tetramer.
How to Order MHC I Dextramer®
Find your MHC I Dextramer reagent in the table below, or
send an e-mail to email@example.com specifying:
- Cat. no or the MHC allele-peptide combination of the MHC I Dextramer reagent. Please check out our current list of available MHC alleles and calculate the predicted peptide-MHC affinity between the MHC allele and the peptide of your choice, using this prediction tool
- Fluorophore (PE, APC, or FITC) or no Fluorophore (None)
- Test sizes (50, 150, 500, 1000 tests). One test is defined as 10 µl MHC-Dextramer reagent, sufficient to stain up to 1-3 x 10^6 lymphoid cells, or 1-3 x 10^5 clonal antigen-specific T cells.
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Measure SARS-CoV-2-specific T-cell Immunity
Evaluate vaccine and disease-induced virus-specific immune responses with MHC I and II Dextramer® reagents.