The backbone of precision immune monitoring
MHC II Dextramer® – Identify Antigen-Specific CD4+ T Cells
Enhanced Sensitivity for Reliable Results
Typically expressed on the surface of antigen-presenting cells, MHC II molecules dock and primes CD4+ T cells.
Antigen-specific CD4+ T cells are critical for the immune response of many diseases, given their role in recruiting and coordinating other immune cells. Often challenging to detect and stratify with standard reagents, antigen-specific CD4+ T cells are revealed through the high-avidity and enhanced sensitivity of the Dextramer® technology.
With multiple MHC-peptide complexes and fluorophores on a flexible dextran backbone, MHC II Dextramer® reagents are designed for high-resolution characterization of CD4+ T-cell responses, even with low-abundance cells and in complex matrices like blood.
MHC II Dextramer® detects DRB1*0101/EBV-specific T cells in a blood sample via flow cytometry (internal data).
A Tool For Meticulous And Precise Research
Push the boundaries of your flow cytometry assays with MHC II Dextramer® reagents. Designed for high avidity and exceptional signal-to-noise ratio, MHC II Dextramer® reagents enable you to detect antigen-specific CD4+ T cells with confidence.
- Get the full picture of CD4+ T-cell responses, even the low-affinity ones.
- Ensure consistent, reproducible, and comparable results.
- Expand the limits of your research.
- Secure flexibility in your experiments.
Discover Dextramer® Controls
Order MHC II Dextramer®
You can order MHC II Dextramer® reagents in one of three ways:
- Use the table below to find and order your MHC II Dextramer® reagent
- If you can’t find the reagent to meet your research needs, create a custom reagent
- Alternatively, send an e-mail to ordering@immudex.com specifying:
- Catalog number or desired MHC allele-peptide combination.
- Consult our lists of available MHC alleles
- Calculate the predicted MHC-peptide affinity using our prediction tool - Fluorophore (PE, APC, FITC, or none)
- Test size (50,150, 500, 1000 tests). One test is 10 µl reagent and sufficient to stain 1–3 x 10^6 lymphoid cells or 1–3 x 10^5 clonal antigen-specific T cells.
Immudex has updated the catalog numbers. To learn more about it, please consult the document here
|
Cat. No. |
Allele | Peptide | Antigen | Disease/Organism |
| FA10001 | DRB1*0101 | PKYVKQNTLKLAT | HA | Influenza |
| FA10002 | DRB1*0101 | PVSKMRMATPLLMQA | CLIP | Endogenous Ag |
| FA10003 | DRB1*0101 | TSLYNLRRGTALA | EBNA1 | EBV |
| FA10004 | DRB1*0101 | PEQWMFQGAPPSQGT | EBNA3A | EBV |
| FA10005 | DRB1*0101 | QEIYMQHTYPISA | Tetanus Toxin | Tetanus |
| FA10006 | DRB1*0101 | LPLKMLNIPSINVH | pp65 | CMV |
| FB10001 | DRB1*0401 | PKYVKQNTLKLAT | HA | Influenza |
| FB10002 | DRB1*0401 | PVSKMRMATPLLMQA | CLIP | Endogenous Ag |
| FB10012 | DRB1*0401 | GAGSLQPLALEGSLQKRG | Proinsulin | Diabetes |
| FB10013 | DRB1*0401 | IAFTSEHSHFSLK | GAD65 | Diabetes |
| FB10014 | DRB1*0401 | NFIRMVISNPAAT | GAD65 | Diabetes |
| FD10001 | DRB1*1101 | PKYVKQNTLKLAT | HA | Influenza |
| FD10002 | DRB1*1101 | PVSKMRMATPLLMQA | CLIP | Endogenous Ag |
| FD10020 | DRB1*1101 | EHPTFTSQYRIQGKL | pp65 | CMV |
| FH10002 | DPB1*0401 | PVSKMRMATPLLMQA | CLIP | Endogenous Ag |
| FH10035 | DPB1*0401 | SLLMWITQCFLPVF | NY-ESO | Cancer |
| FH10036 | DPB1*0401 | TQHFVQENYLEY | MAGE-A3 | Cancer |
| FH10037 | DPB1*0401 | KKYFAATQFEPLA | Oxytocinase | Cancer |
| FI10187 | HLA-DQ2.5 | QLQPFPQPELPY | α-I, Gliadin | Celiac disease |
| FI10188 | HLA-DQ2.5 | GMATPLLMQALPMGAL | CLIP2 | Endogenous Ag |
| Test Size | Price (EUR) | Price (USD) |
| 50 tests | 1.420* | 1,630* |
| 150 tests | 2.730* | 3,150* |
| 500 tests | 6.510* | 7,460* |
| 1000 tests | 11.350* | 12,975* |
* For customized products an entry fee of 575EUR / 675USD is added to evaluate each unique peptide's ability to bind to the requested MHC II allele using standardized peptide binding assays.