MHC II Dextramer® – Identify Antigen-Specific CD4+ T Cells

Enhanced Sensitivity for Reliable Results

Typically expressed on the surface of antigen-presenting cells, MHC II molecules dock and primes CD4+ T cells.

Antigen-specific CD4+ T cells are critical for the immune response of many diseases, given their role in recruiting and coordinating other immune cells. Often challenging to detect and stratify with standard reagents, antigen-specific CD4+ T cells are revealed through the high-avidity and enhanced sensitivity of the Dextramer® technology.

With multiple MHC-peptide complexes and fluorophores on a flexible dextran backbone, MHC II Dextramer® reagents are designed for high-resolution characterization of CD4+ T-cell responses, even with low-abundance cells and in complex matrices like blood.

Dextramer® Technology

The backbone of precision immune monitoring

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MHC Dextramer® Protocol

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MHC II Dextramer® detects DRB1*0101/EBV-specific T cells in a blood sample via flow cytometry (internal data).

A Tool For Meticulous And Precise Research

Push the boundaries of your flow cytometry assays with MHC II Dextramer® reagents. Designed for high avidity and exceptional signal-to-noise ratio, MHC II Dextramer® reagents enable you to detect antigen-specific CD4+ T cells with confidence.

Get the full picture of CD4+ T-cell responses, even the low-affinity ones.
Ensure consistent, reproducible, and comparable results.
Expand the limits of your research.
Secure flexibility in your experiments.

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Order MHC II Dextramer®

You can order MHC II Dextramer® reagents in one of three ways:

Use the table below to find and order your MHC II Dextramer® reagent
If you can’t find the reagent to meet your research needs, create a custom reagent
Alternatively, send an e-mail to ordering@immudex.com specifying:

Catalog number or desired MHC allele-peptide combination.
- Consult our lists of available MHC alleles
Fluorophore (PE, APC, FITC, or none)
Test size (50,150, 500, 1000 tests). One test is 10 µl reagent and sufficient to stain 1–3 x 10^6 lymphoid cells or 1–3 x 10^5 clonal antigen-specific T cells.

Immudex has updated the catalog numbers. To learn more about it, please consult the document here

Cat. No.	Allele	Peptide	Antigen	Disease/Organism
FA10001	DRB1*0101	PKYVKQNTLKLAT	HA	Influenza
FA10002	DRB1*0101	PVSKMRMATPLLMQA	CLIP	Endogenous Ag
FA10003	DRB1*0101	TSLYNLRRGTALA	EBNA1	EBV
FA10004	DRB1*0101	PEQWMFQGAPPSQGT	EBNA3A	EBV
FA10005	DRB1*0101	QEIYMQHTYPISA	Tetanus Toxin	Tetanus
FA10006	DRB1*0101	LPLKMLNIPSINVH	pp65	CMV
FB10001	DRB1*0401	PKYVKQNTLKLAT	HA	Influenza
FB10002	DRB1*0401	PVSKMRMATPLLMQA	CLIP	Endogenous Ag
FB10012	DRB1*0401	GAGSLQPLALEGSLQKRG	Proinsulin	Diabetes
FB10013	DRB1*0401	IAFTSEHSHFSLK	GAD65	Diabetes
FB10014	DRB1*0401	NFIRMVISNPAAT	GAD65	Diabetes
FD10001	DRB1*1101	PKYVKQNTLKLAT	HA	Influenza
FD10002	DRB1*1101	PVSKMRMATPLLMQA	CLIP	Endogenous Ag
FD10020	DRB1*1101	EHPTFTSQYRIQGKL	pp65	CMV
FH10002	DPB1*0401	PVSKMRMATPLLMQA	CLIP	Endogenous Ag
FH10035	DPB1*0401	SLLMWITQCFLPVF	NY-ESO	Cancer
FH10036	DPB1*0401	TQHFVQENYLEY	MAGE-A3	Cancer
FH10037	DPB1*0401	KKYFAATQFEPLA	Oxytocinase	Cancer
FI10187	HLA-DQ2.5	QLQPFPQPELPY	α-I, Gliadin	Celiac disease
FI10188	HLA-DQ2.5	GMATPLLMQALPMGAL	CLIP2	Endogenous Ag
FC10002	DRB1*1501	PVSKMRMATPLLMQA	CLIP	Endogenous Ag
FC10049	DRB1*1501	ISMYTFSTMKANVGMGR	Large T antigen	Progressive multifocal leukoencephalopathy/JC Polyomavirus
FC10055	DRB1*1501	PVDLHAFLSQAVFS	Large T antigen	Progressive multifocal leukoencephalopathy/JC Polyomavirus
FC10063	DRB1*1501	ENPVVHFFKNIVTPR	Myelin basic protein	Multiple sclerosis
FC10113	DRB1*1501	RVLGLVLLRGENLVS	SNRBP	Cancer - Glioblastoma
FC10125	DRB1*1501	SLLKKYLTKEVFDKL	Arginine kinase Lit v 2	Shrimp allergy/Penaeus vannamei
FC10144	DRB1*1501	KGIFVIQSESLKKCI	Phospholipase A2 Receptor 1	Idiopathic Membranous Nephropathy
FC10145	DRB1*1501	NANMTWYAAIKTCLM	Phospholipase A2 Receptor 1	Idiopathic Membranous Nephropathy
FC10158	DRB1*1501	ENPVVHFFKNIVTPRTP	Myelin basic protein	Multiple sclerosis
FC10159	DRB1*1501	MEVGWYRPPFSRVVHLYRNGK	Myelin oligodendrocyte glycoprotein	Multiple sclerosis

Test Size	Price (EUR)	Price (USD)
50 tests	1.435*	1,645*
150 tests	2.760*	3,185*
500 tests	6.575*	7,535*
1000 tests	12.495*	14,315*

* For customized products an entry fee of 575EUR / 675USD is added to evaluate each unique peptide's ability to bind to the requested MHC II allele using standardized peptide binding assays.