Harnessing the Immune System in the Fight Against Cancer

Immunity-Informed Decisions about Cancer Treatments

Guided to recognize cancer cells, the human cellular immune response has the power to mount a fast and fierce attack on tumors. A key aspect of immunotherapeutic strategies is the detailed monitoring of cancer-specific T-cell populations in patients to detect existing or induced immunity, understand immune escape, and track patient response to treatments.

Immudex has specific reagents as well as predefined Dextramer® panels to detect, quantify and isolate these cell populations. Alternatively, design Dextramer® reagents to match your cancer immune monitoring.

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New Therapies from Unraveled Immune Complexity

Reactions of the immune system to the presence of cancer cells are complex and varied. A diversity of immune cells interact in a collective response, each with different receptor affinities to specific tumor antigens. Elucidating that complexity can reveal new modes of action for potential therapies.

Dextramer® reagents detect and characterize the complete spectrum of cells involved in the cellular immune response, including low-affinity CD8+ and CD4+ T cells.

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Existing Cellular Immunotherapies Leverage Different Immune Cells in Personalized Cancer Treatments

T cells

T cells that have infiltrated a tumor (TILs) can be isolated, activated, expanded, and reinfused into the patient to mount a strong attack on the tumor. The same cells may also be equipped with a new receptor (TCR) to target specific cancer antigens.

Monitor cancer-specific CD8+ T cells

 

CAR-T cells

T cells engineered with cancer-targeting chimeric antigen receptors (CARs), with the ability to target a specific protein. They are designed to recognize highly specific antigens and either kill tumor cells or modulate immune responses.

Read about this strategy

NKT cells

Activated natural killer T (NKT) cells fight cancer directly in an antigen-specific cytotoxic attack. They can also activate other immune cells. The activity of these unique cells is CD1d-dependent, opening the opportunity to detect them in samples.

Identify and track NKT cells

B cells

B cells produce antibodies and act as potent antigen-presenting cells to induce antitumor-specific T-cell responses. With well-defined epitopes and sensitive reagents, diverse B-cell populations can be stratified and their role in immunity revealed.

Discover B-cell diversity

Human Cancer Epitopes

Review our comprehensive list of published human cancer T-cell epitopes.

Mouse Cancer Epitopes

Discover the comprehensive list of murine models and cancer T-cell epitopes.

Case Studies

Discover the impact of Dextramer® technology in case studies in the field of cancer research

Publications

Learn about the uses, experiences, and finding in cancer research in our list of publications.