Dextramer® Performance Data

Don’t Risk Missing Crucial Information

Dextramer® reagents are designed with the needs of researchers and clinicians worldwide in mind, ensuring high sensitivity and reproducible results.

Uncover T cells That Other Technologies Miss

Dextramer® reagents are optimized with a high number of MHC-peptide complexes that increase the avidity for T cells, allowing you to monitor also low-affinity T-cell receptors (TCR).
Staining with Dextramer® reagents allows detecting antigen-specific T cells that tetramer cannot detect (Dolton et al., 2018). This new level of sensitivity can uncover antigen-specific populations that could not previously be identified.
In high-affinity TCR, Dextramer® reagents show a higher fluorescence resolution than tetramer.

 

 

Ensure the Highest Resolution

The high number of fluorophores attached to the dextran backbone increases the fluorescence intensity of the antigen-specific cells detected.
Dextramer® reagents provide you with a better cell visualization thanks to achieving a fluorescence intensity three folds higher than other multimers.

 

 

Get a Clear Picture – Highest Resolution With the Lowest Background

Ensure the highest resolution with the lowest background.
Compared to other multimer technologies (pentamers and tetramers), Dextramer® reagents can identify antigen-specific T cells, ensuring the highest resolution and the lowest background staining.

 

 

High-Quality Reagents for Your Research

An internal comparison study was run with three different batches of MHC I Dextramer® reagents specific for EBV, CMV (two different peptides), and Flu.
The study showed that the percentage of CD8+ antigen-specific T cells identified with each batch is comparable.

Scientific Insights and References

Challenge the Limits of Immune Monitoring