Immune Monitoring for Autoimmunity

Deciphering Immune Cell Activity in Autoimmune Conditions

Autoreactive T cells are key mediators of abnormal immune responses against a patient’s own healthy cells – a situation that manifests itself in a broad spectrum of conditions from celiac disease to rheumatoid arthritis, multiple sclerosis, and diabetes mellitus type 1.

Both CD8+ and CD4+ T cells have long been implicated in autoimmunity. Given their role in recruiting and coordinating other immune cells, CD4+ T cells are particularly important for immune monitoring.

A New Perspective for Chronic Diseases​


With documented increases in incidence, diabetes and celiac disease are significant burdens on global healthcare. Interrogating CD8+ and CD4+ T cells by flow cytometry allows clinicians to identify and enumerate antigen-specific populations to improve diagnosis, treatment, and ultimately prognoses for patients.

With boosted avidity and an extensive menu of allele-peptide combinations, MHC class I and MHC class II Dextramer® reagents are effective tools to monitor autoreactive CD8+ and CD4+ T cells.

Capture Signatures of Autoimmunity with Dextramer® Reagents

Discover a curated selection of our autoimmune-specific reagents

MHC I Dextramer® reagents to detect antigen-specific CD8+ T cells

 

Cat. No.

Allele

Peptide

Antigen

Category/Disease

WB2744

HLA-A*0201

YTCPLCRAPV

SAA

Autoimmune

WB3405

HLA-A*0201

VMNILLQYVV

GAD65

Diabetes

WB3402

HLA-A*0201 

YAYDGKDYIA

HLA-A2

Diabetes

WB3406

HLA-A*0201

MVWESGCTV

IA-2

Diabetes

WB3560

HLA-A*0201

VIVMLTPLV

IA-2

Diabetes

WB3448

HLA-A*0201

LNIDLLWSV

IGRP

Diabetes

WB3329

HLA-A*0201

VLFGLGFAI

IGRP

Diabetes

WB3404

HLA-A*0201

ALWGPDPAAA

Insulin

Diabetes

WB3403

HLA-A*0201

HLVEALYLV

Insulin

Diabetes

WB3481

HLA-A*0201

FLLSLFSLWL

ZnT-8

Diabetes

WB3482

HLA-A*0201

HIAGSLAVV

ZnT-8

Diabetes

WB3483

HLA-A*0201

ILKDFSILL

ZnT-8

Diabetes

WB3484

HLA-A*0201

VVTGVLVYL

ZnT-8

Diabetes

 

To order your MHC I reagents, visit our MHC I Dextramer® page​

MHC II Dextramer® reagents to detect antigen-specific CD4+ T cells

 

Cat. No.

Allele

Peptide

Antigen

Category/Disease

FI10187

HLA-DQ2.5

QLQPFPQPELPY

α-I, Gliadin

Celiac Disease

FI10188

HLA-DQ2.5

GMATPLLMQALPMGAL

CLIP2

Endogenous Ag

FB10012

DRB1*0401 

GAGSLQPLALEGSLQKRG

Proinsulin

Diabetes

FB10013

DRB1*0401 

IAFTSEHSHFSLK

GAD65

Diabetes

FB10014

DRB1*0401 

NFIRMVISNPAAT

GAD65

Diabetes

 

To order your MHC II reagents, visit our MHC II Dextramer® page