U-Load

Build Custom Dextramer® Reagents in Your Lab

With ingenious design, U-Load Dextramer® makes broad allele coverage and the use of your own peptides easy and fast

 

U-Load Dextramer® is a novel reagent concept that allows you to combine custom MHC-peptide complexes with the benefits of the Dextramer® technology. The empty U-Load Dextramer® binds biotinylated monomers of your choice from a broad range of MHC I and MHC II alleles and custom antigenic peptides. Minimize time and money spent to screen large numbers of specificities and samples by easily assembling quality reagents with a simple protocol that takes 1 hour and can be done at your workbench.

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U-Load Flow Cytometric Data

Comparable staining was achieved with U-Load Dextramer® and MHC Dextramer® reagents.

Whether via flow cytometry or next-generation sequencing (NGS), push the boundaries of what you can detect

 

  • Create fit-for-purpose immune monitoring reagents in your lab
  • Access the broadest human allele coverage on the market
  • Eliminate high reagent costs for high-throughput screening
  • Implement Dextramer® sensitivity and specificity in any project
  • Simplify your work: fast and easy protocol with no UV-radiation

Ultimate Flexibility, Reliable Sensitivity

Build Custom Dextramer® Reagents

Transform Your Research Strategy with U-Load

easYmer® and U-Load MHC II: MHC I and MHC II monomers

Purchase MHC I and MHC II monomers covering a broad range of allotypes to optimize the antigen component of your U-Load Dextramer® reagent or to build your own multimer.

MHC I and MHC II U-Load Dextramer® Kits

Everything you need to easily build high-avidity T-cell monitoring reagents for flow cytometric analysis. Pick a fluorophore, an allotype monomer, and get started.

MHC I and MHC II U-Load dCODE Dextramer®

Boost the granularity of your sequencing-based monitoring of T-cell populations. Choose your DNA-barcoded dextran backbone (HiT, RiO, or 10x), the desired allotype monomer, and your own peptide.

 

The Allotype Coverage to Truly Explore Human Immune Diversity

Access the broadest available allele coverage in the market.
Select from 40 human and 2 mouse allotypes for MHC I and 4 human allotypes for MHC II and build the U-Load Dextramer® that best suits your T-cell research.

 

Discover the allele list

Data obtained from Gonzalez-Galarza et al. (2020) "Allele frequency net database (AFND) 2020 update: gold-standard data classification, open access genotype data and new query tools." Nucleic Acids Res. Jan 8; 48(D1): D783–D788

Order MHC I and MHC II U-Load Dextramer® Kits

 

Immudex MHC I and MHC II U-Load Dextramer® Kits bring the flexibility of constructing your own precision immune monitoring reagents for flow cytometry to your lab.

All you add is your antigen peptide of interest. Each kit contains:

  • Stabilizing dextramer backbone (U-Load Dextramer®) designed to be loaded with your peptide-MHC complex
  • Your choice of fluorophore: APC, FITC, PE, or none
  • Your selection of MHC allele monomers
  • A positive control peptide allowing evaluation of proper refolding of peptide-loaded complexes

U-Load Dextramer® MHC I Kit

To order U-Load Dextramer® MHC I Kit, please send an e-mail to ordering@immudex.com specifying your selection of easYmer®, your choice of fluorophore, and your desired test size.

Number of Tests Price (EUR) Price (USD)
20
450
540
50 1050 1250
150 2475 2970

U-Load Dextramer® MHC II Kit

To order U-Load Dextramer® MHC II Kit, please send an e-mail to ordering@immudex.com specifying your selection of U-Load MHC II, your choice of a fluorophore, and your desired test size.

Number of Tests Price (EUR) Price (USD)
50 1050 1250
150 2475 2970

 

For more information about the product or interest in a bigger number of tests, please contact us at customer@immudex.com

For research use only. Not for use in diagnostic or therapeutic procedures.