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Reliable Identification of SARS-CoV-2-Specific T-Cell Responses

Explore T-Cell Immunity in COVID-19

A deeper understanding of virus-specific T-cell responses to COVID-19 is needed to evaluate vaccine candidates, explore long-term immunity, predict patients at risk, and even prepare for the next pandemic.

Dextramer® technology can help you monitor and characterize SARS-CoV-2- specific CD4+ and CD8+ T cells in blood, without missing rare or low-affinity cells, in an easy and reproducible way.

Learn More about T Cells and COVID-19

Frequencies of SARS-CoV-2-specific CD8+ T cells detected in PBMCs at different time points from a vaccinated convalescent donor with a SARS-CoV-2 MHC I Panel of Non-Spike Epitopes.

Add a custom product - MHC I

Allele	Peptide	Dye	Size	Cat. No.	Price	Buy
				CUSTOM-01	$1,490.00 $2,645.00 $6,410.00 $12,185.00

Add a custom product - MHC II

Allele	Peptide	Dye	Size	Cat. No.	Price	Buy
				CUSTOM-02	$1,645.00 $3,185.00 $7,535.00 $14,315.00

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PEPTIDE

ANTIGEN

SARS-CoV-2 Dextramer® Reagents

All SARS-CoV-2 Dextramer® reagents are available for detection of antigen-specific T cells by in-situ staining, flow cytometry, NGS or single-cell multi-omics. All specificities listed below are also available as MHC Monomers.

MHC I or MHC II Dextramer® - for identification of antigen-specific T cells by flow cytometry

dCODE Dextramer® (HiT) - for bulk analysis of antigen-specific T cells by PCR and NGS

dCODE Dextramer® (10x) - for single-cell multi-omic analysis of antigen-specific T cells to combine information on TCR recognition, TCR sequencing, and gene expression using 10x Chromium Single Cell analysis.

dCODE Dextramer® (RiO) - for single-cell multi-omic analysis of antigen-specific T cells to combine information on TCR recognition, TCR sequencing, and gene expression using BD Rhapsody^TM Single-Cell Analysis.

MHC I or MHC II Monomers – for flexible investigation of antigen-specific T cells

MHC Dextramer® Reagents

dCODE Dextramer® Reagents

SARS-CoV-2 Dextramer® Panels

We provide SARS-CoV-2 Dextramer® reagents in panels targeting Spike or Non-Spike epitopes, each with a selection of validated T-cell epitopes.

Alternatively, select your own custom panel based on our selection of SARS-CoV-2 Dextramer® reagents, or order individual Dextramer® reagents.

The immunodominant SARS-CoV-2 specific T-cell epitopes listed below are known to be present in large populations, based on publications and in-house knowledge, enabling researchers to monitor T-cell immunity across COVID-19 variants.

SARS-CoV-2 MHC I Panel of Spike Epitopes

Allele	Peptide	Antigen	Delta	Omicron BA 2.12.1	Omicron BA.4	Omicron BA. 5
A*0101	LTDEMIAQY	S
A*0101	WTAGAAAYY	S
A*0201	YLQPRTFLL	S
A*0201	FIAGLIAIV	S
A*0301	KCYGVSPTK	S
A*0301	GVYFASTEK	S		GVYFASIEK
A*1101	RLFRKSNLK	S
A*1101	KCYGVSPTK	S
A*1101	GVYFASTEK	S		GVYFASIEK
A*2402	QYIKWPWYI	S
A*2402	NYNYLYRLF	S	NYNYRYRLF		NYNYRYRLF	NYNYRYRLF
B*0702	SPRRARSVA	S	SRRRARSVA	SHRRARSVA	SHRRARSVA	SHRRARSVA
B*0702	APHGVVFL	S
B*3501	QPTESIVRF	S
B*3501	LPFNDGVYF	S
B*3501	IPFAMQMAY	S

Spike-specific CD8+ T-cell epitopes in the SARS-CoV-2 Dextramer® Panels, and the conservation of these epitopes across the SARS-CoV-2 Delta (B.1.617.2) and Omicron (BA 2.12.1, BA. 4, BA. 5) variants. All epitopes are conserved in the reference strain (NC_045512). Mutations in the epitope are shown in red. Learn more in this Application Note.

SARS-CoV-2 MHC I Panel of Non-Spike Epitopes

Allele	Peptide	Antigen	Delta	Omicron	Omicron BA.4	Omicron BA. 5
A*0201	LLLDRLNQL	N
A*0301	KTFPPTEPK	N
A*1101	KTFPPTEPK	N
B*0702	SPRWYFYYL	N
A*0101	FTSDYYQLY	ORF3a
A*0201	LLYDANYFL	ORF3a
A*2402	VYFLQSINF	ORF3a
A*0101	TTDPSFLGRY	ORF1ab	TTDLSFLGRY
A*0201	ALWEIQQVV	ORF1ab
A*0301	VVYRGTTTYK	ORF1ab
A*1101	ASMPTTIAK	ORF1ab
A*2402	VYIGDPAQL	ORF1ab
B*0702	IPRRNVATL	ORF1ab

Non-Spike-specific CD8+ T-cell epitopes in the SARS-CoV-2 Dextramer® Panels, and the conservation of these epitopes across the SARS-CoV-2 Delta (B.1.617.2), and Omicron (BA 2.12.1, BA. 4, BA. 5) variants. Green = no mutations in epitope, Red = mutations in epitope. All epitopes are conserved in the reference strain (NC_045512). Mutations in the epitope are shown in red. Learn more in this Application Note.

Order your SARS-CoV-2 Panels

Please contact our application specialist if you would like to discuss your research.

Please include information on:

Your preferred epitope(s) and alleles for MHC Dextramer®, dCODE Dextramer®, or MHC Monomer
Your preferred reagent format: MHC Dextramer® or dCODE Dextramer®
Your preferred dye (for MHC Dextramer®): PE, APC, FITC, or None
Test size:
o MHC Dextramer®, select between 50 or 150 tests
o dCODE Dextramer®, select between 25, 50, or 150 tests
o MHC Monomers select between 20 µg (~50 tests), 100 µg (~250 tests), or 200 µg (~500 tests)

Published Human COVID-19 T-Cell Epitopes

Download the list of epitopes in COVID-19 infected or vaccinated individuals

Download the list

Published Mouse COVID-19 T-Cell Epitopes

Download the list of epitopes in COVID-19 infected genetically modified mice.

Download the list

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