Reliable Identification of SARS-CoV-2-Specific T-Cell Responses

Spike proteins of SARS-CoV-2 play a key role in the receptor recognition and cell membrane fusion process. Many COVID-19 vaccine development programs focus on the spike protein.

Immudex has prepared two curated Dextramer® Panels displaying proven T-cell epitopes from the Spike protein to help researchers evaluate their vaccine candidate's ability to elicit long-term SARS-CoV-2 T-cell immunity.

XL Panel

• Include T-cell epitopes from Spike protein shown to identify virus-specific T-cells in patients in multiple publications. Only epitopes identified in patient cohorts larger than 7 patients. All validated with MHC Multimer studies

S Panel

• Include Top 5 T-cell epitopes from Spike protein shown to identify virus-specific T-cells in patients in multiple publications

HLA-A*0201 is the most common HLA I allele in the European and North American populations.

Immudex has prepared two curated Dextramer® Panels displaying proven SARS-CoV-2 T-cell epitopes restricted by HLA-A*0201 for researchers to measure SARS-CoV-2 specific T cells and get a deeper understanding of the COVID-19 immunity.

XL Panel

• Include the most well-defined A*0201 restricted epitopes from 7 SARS-CoV-2 antigens, shown to identify virus-specific T-cells in patients in multiple publications. All validated with MHC Multimer studies

S Panel

• Include the top 5 most immune dominant epitopes from XL panel with high patient coverage in multiple publications

Immudex keeps a curated and updated list of the published SARS-CoV-2 epitopes shown to be recognized by T cells in COVID-19 patients. We have created two curated Dextramer® Panels comprising the most immune dominant SARS-CoV-2 T-cell epitopes published in at least two publications.

With these two unique Panels, you get access to measure SARS-CoV-2 T-cell responses in a broad patient cohort following infections or vaccinations.

XL Panel

• Include T-cell epitopes shown to identity virus-specific T cells in patients in multiple publications. Covers 4 SARS-CoV-2 Antigens and 6 HLA Alleles

S Panel

• Include the most immune dominant T-cell epitope(s) for each allele and is a subset of the XL panel. Covers 4 SARS-CoV-2 antigens and 6 HLA alleles. All have high patient coverage in multiple publications

We are well aware that not all patients cohorts are the same and that sometimes, you are the only one able to design the Panel most suitable for your research.

Choose your preferred SARS-CoV-2 specific reagents and build your customized package. Have a look at the continuously updated list of the published COVID-19 T-cell epitopes.

SARS-CoV-2 Custom Panel
As many epitopes as you like 

• Include:
  - T-cell epitopes from your own selection
  - T-cell epitopes from Immudex SARS-CoV-2 Panels or epitope list
• Alleles: any MHC I or MHC II from our catalog