Live Webinar: Evaluation of TCR-pMHC Affinity and its Implications

for T Cell Therapies

This webinar will cover: 

• Challenges associated with production of high quality TCR monomers suitable for TCR affinity measurement 

• The importance of TCR affinity measurement in the context of development of T cell therapies 

• Introduction to two techniques used for affinity measurement: Surface Plasmon Resonance and Biolayer Interferometry, and the advantages/disadvantages of each technique 
• Results of a case study investigating the interaction between a modified affinity-enhanced TCR targeting the NY-ESO I antigen and its cognate pMHC (HLA-A*0201 / SLLMWITQC) in terms of affinity and kinetics 
• Recommendations on best practices for TCR-pMHC affinity measurement

The live webinar will consist of a 30-minute presentation followed by a Q&A session. 

You can choose from two live sessions. 

Speakers

• Fabian Vandermeers, PhD - R&D Technical Leader, Quality Assistance 

• Lyn Zhu - R&D Scientist, Immudex

Immudex and Quality Assistance Partner on TCR Affinity Measurement Services 

This service enables, for example, determination of the dissociation constant (Kd) and investigation of the specificity of the TCR:pMHC interaction by evaluating the interaction with a cognate pMHC compared to an off-target pMHC. 

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About Quality Assistance

Quality Assistance is a leading European Contract Research Organisation providing the pharmaceutical industry with all the analytical services required by EMA and FDA regulations for the development and marketing of innovative human medicinal products.

Quality Assistance holds a unique place on the market with all of its laboratories on one site in Belgium, 250 highly-qualified professionals and more than 40 years’ expertise at the forefront of analytical sciences.

The company assists its clients from candidate selection, through non-clinical and clinical studies, to marketing authorisation, using our state-of-the-art, product-dedicated expertise in analytical sciences. Quality Assistance designs customised solutions, define analytical protocols, develop and validate specific new analytical methods and perform characterisation, stability, pharmacokinetic, biomarker and immunogenicity studies as well as batch release testing, in order to evaluate the Quality, Safety and Efficacy of the given drugs.

Meet our Technical Support Team

Jaime James, PhD

Technical Application Scientist

Patricia Santos, PhD

Technical Application Scientist