T-cells Take the Lead in COVID-19

CD4+ and CD8+ T-cell responses to SARS-CoV-2 are crucial for initially resolving acute viral infection and later to assist protection against reinfection through immunological memory (long-lasting immunity).

Monitoring T-cell responses to numerous epitopes provide a clear picture of the immunity in recovering patients and highlight the potential to pursuit epitopes from multiple antigens as targets for immunotherapies and vaccines.

What remains to be learned?

Much has been learned about COVID-19 immunity in 2020.
However, many open questions crucial for fighting the disease still exist:

• Will the first vaccines provide long-lasting immunity?
• What is the efficacy of a vaccine?
• Do some people have pre-existing immunity to SARS-CoV-2?
• Are some T-cell epitopes immunodominant?
• Are disease severeness reflected in the immunological response?

We can help you study COVID-19 immunity

Immudex Dextramer® Technology can help you:

• Facilitate SARS-CoV-2-specific epitope discovery
• Monitor T-cell immunity in COVID-19 infected/vaccinated subjects
  
• Assess the ability of vaccine candidates to elicit efficient T-cell responses in hosts
  

COVID-19 Specific Dextramer® Products

With SARS-CoV-2-epitopes provided by you or from the curated list of published COVID-19 T-cell epitopes you can customize any of the following products. Customized reagents are easily made with HLA-alleles from our catalog and with epitopes that form stable complexes with the MHC molecule.

• MHC I and II Dextramer® reagents can visualize virus-specific CD4+ and CD8+ T cells in blood samples by flow cytometry.
  
  
• dCODE Dextramer ® (HiT) Technology for epitope discovery or T-cell profiling in bulk solution. The unique DNA barcode enables the detection of antigen-specific T cells by PCR followed by Next Generation Sequencing.
  
  
• COVID-19 dCODE Dextramer® Panels allow you to make a full multi-omic profile of the virus-specific immune response by detecting antigen-specific T cells and their T-cell receptor sequencing at the single-cell level. Use a predefined panel or design your own selection of T-cell epitopes.

Please contact us today to hear more about our COVID-19-specific products, and let us help you find the best solution for your project.

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