Don’t Risk Missing Crucial Information
Dextramer® reagents are designed with the needs of researchers and clinicians worldwide in mind, ensuring high sensitivity and reproducible results.
Detect T cells That Other Technologies Miss
Dextramer® reagents are optimized with a high number of peptide-MHC complexes that increase the avidity for T cells, allowing you to monitor also low-affinity T-cell receptors (TCR).
Staining with Dextramer® reagents enables the detection of antigen-specific T cells that tetramer cannot detect (Dolton et al., 2014). This new level of sensitivity can uncover antigen-specific populations that could not previously be identified.
Ensure the Highest Resolution
The high number of fluorophores attached to the dextran backbone increases the fluorescence intensity of the antigen-specific cells detected.
Compared with conventional multimers, MHC Dextramer® reagents provide you with higher MFI (median fluorescence intensity), resulting in a clearer separation of the positive T cell population.
Detection of Tumor Infiltrating Lymphocytes. Resolution and MFI using MART1 Dextramer® is three times higher than with Tetramer.
Get a Clear Picture – Highest Resolution With the Lowest Background
Ensure the highest resolution with the lowest background.
Compared to conventional multimer technologies (pentamers and tetramers), higher order Dextramer® reagents can identify antigen-specific T cells with higher resolution and lower background staining.
Since proper controls are at the core of every experiment, we have developed innovative Dextramer® Peptide Pool Negative Controls for a range of different alleles.
High Quality Reagents for Your Research
Rigorous quality control is a core part of our manufacturing process.
An internal comparison study was run with three different batches of MHC I Dextramer® reagents specific for EBV, CMV (two different peptides), and Flu.
The study showed that the percentage of CD8+ antigen-specific T cells identified with each batch is comparable.
