Custom MHC Dextramer®

Our experts evaluate the feasibility of producing custom MHC Dextramer® and MHC Monomers

Need an MHC Dextramer® or MHC Monomer with a custom peptide?

Contact us with your desired allele and peptide sequence and our experts will evaluate the feasibility of producing a custom MHC Dextramer® or MHC Monomer for you. Here you can find our MHC Allele List.

We incorporate in silico analyses based on established platforms such as NetMHC¹ to investigate the predicted stability of any novel peptide-MHC combination we haven’t yet produced. By including the in silico analysis in our workflow, we can assess the likelihood of successfully delivering a stable peptide-MHC complex.

We classify the production of the custom MHC Dextramer® reagents or MHC Monomers as either low-risk (in which case the predicted peptide-MHC stability is high) or high-risk (in which case the predicted peptide-MHC stability is low).

Based on our in silico assessment, it is up to you to decide whether you want us to proceed with producing your custom MHC Dextramer® or MHC Monomer.

Entry Fees for Custom MHC Dextramer® and Custom MHC Monomers

For custom MHC-peptide combinations, we charge a one-time entry fee to evaluate each unique peptide's ability to bind to the requested MHC allele using a peptide-MHC complex integrity assay.

Production of Custom MHC Dextramer®

We will only deliver the custom MHC Dextramer® reagent to you if it meets our rigorous quality control standards.

If the production of the custom MHC Dextramer® reagent is unsuccessful, unfortunately we will not be able to deliver a product to you. In this case, we will only charge you the entry fee for pMHC combinations deemed low-risk by the in silico assessment. However, for pMHC combinations deemed high-risk by the in silico assessment, we will charge you the entry fee plus the full price of the reagent.

We hope that by providing in silico assessment of peptide-MHC stability you can make informed decisions about your choice of custom Dextramer® reagents.

¹For in silico assessment of peptide-MHC stability, we use NetMHC 4.0 for MHC I and NetMHCIIpan 4.3 for MHC II.

Custom Alleles

If your allele of interest is not included in our allele list, please contact us and we can manufacture new Custom Alleles on request via our Custom Solutions and Services team.

Questions? 

If you're interested in Custom MHC Dextramer® or have questions related to your research, please complete the form, and one of our dedicated specialists will contact you shortly.