Single-cell Multi-omics for B cells

  • Link BCR Sequence to cognate antigen: dCODE Klickmer® reagents reveal BCR-antigen interactions.

  • Holistic characterization: Link information on antigen specificity to transcriptomic profiles, surface protein expression, and full-length BCR sequencing, at the single-cell level.

  • Sensitive multiplexing: dCODE Klickmer® reagents combine Dextramer® sensitivity with the power of next-generation sequencing to unlock insights about thousands of B cells.

  • Capture diversity: Perform high-throughput screening of B-cell diversity or detect multiple antigen-specific, antibody-producing B-cell populations for large scale antibody discovery.

  • Flexibility: Compatible with BD Rhapsody™ and 10x Chromium platforms.

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Explore B-cell subsets effortlessly with dCODE Klickmer® reagents. By binding and displaying biotinylated molecules of interest on a Dextran molecule with a DNA barcode, these reagents broaden the applicability of Dextramer® technology and the power of multiplexing to any cell type, including B cells. As a result, no cell remains undetected for a deep characterization of B-cell responses at single-cell level.

Compatible with 10x Chromium and BD Rhapsody™ systems, dCODE Klickmer® reagents detect multiple antigen-specific, antibody-producing B-cell populations and enable comprehensive insights into gene expression, surface proteins, and BCR sequences. You can match BCR and antigens or conduct large-scale, multiplexed antibody discovery; unlock high-resolution B-cell diversity in a single sample; or even profile B and T cells concurrently by combining dCODE Klickmer® and dCODE Dextramer® reagents.

Discover more with dCODE Klickmer®
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