Uncover BCR sequences at single-cell resolution to identify novel antibodies

  • Multiplexed detection: Capture antigen-specific B cells and assess all individually and concurrently thanks to the dCODE® DNA barcode.

  • Sensitive, high-avidity binding: Built on Dextramer® technology, Klickmer® binds B cells specific to a loaded target protein, even B cells with low affinity.

  • Single-cell resolution: Evaluate B-cell antigens and BCR sequences at the level of individual cells.

  • Multi-omic approach: Gain information about gene expression and BCR clonotype on thousands of B cells simultaneously.

  • Support from the start: Our expert team can help plan your analysis, design your reagents, and achieve top-quality results.

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The identification and characterization of antigen-specific B cells are vital for the discovery of therapeutic antibodies. The challenge, however, lies in detecting and analyzing thousands of B cells simultaneously. dCODE Klickmer® addresses this gap. This customized and sensitive tool is loaded with an antigen of interest and allowed to bind antigen-specific B cells.

Built on Immudex’s Dextramer® technology, binding is highly specific and sensitive, even for B cells with low affinity for the antigen. Furthermore, as each dCODE Klickmer® molecule includes a DNA barcode, the captured cells can be evaluated in a single workflow and at single-cell resolution, gaining insights into cell phenotype, gene expression, and BCR clonotype.

"I have already recommended Immudex reagents to current and former colleagues because I am satisfied with the quality of the products and the customer support"

Scientist, Pharmaceutical Company
"I am very happy with the quality of the products and the prompt response by the customer team"

Scientist, Pharmaceutical Company

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See dCODE Klickmer® in action for Antibody Discovery

Discover the entire experiment by downloading the application note.