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- Enhanced sensitivity and specificity: Dextramer® reagents accommodate numerous peptide MHC complexes, promoting multi-binding for increased avidity and enabling longer binding times.
- Capture low-affinity T cells: Dextramer® reagents capture T-cell populations with low-affinity receptors or at low cell counts that may go undetected by conventional MHC multimers.
- Strong signal and reduced background: Each Dextramer® molecule includes multiple fluorophores to produce unambiguous staining and boost the signal-to-noise ratio.
- Versatility for in-depth research: dCODE Dextramer® enhances standard Dextramer® reagents with DNA barcoding for multiplexed processing and multi-omic analyses
- Reliability: Stringent quality standards in manufacturing ensure consistent and reliable results.
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Overcome limitations of conventional detection reagents and perform antigen-specific T cell sorting and gating via flow cytometry with unmatched sensitivity and specificity. MHC I and MHC II Dextramer® reagents have a flexible configuration that binds CD4+ and CD8+ T cells with heightened avidity.
As a result, flow cytometry gating and sorting captures even low-affinity T cells, revealing population subsets and antigen-specific T cell responses in high resolution. Furthermore, DNA barcoding with dCODE Dextramer® enables multi-omic analyses. Produced under stringent quality standards, Dextramer® reagents generate consistent and reproducible results every time.
Discover more with MHC I and MHC II Dextramer® reagents
"A thorough analysis of antigen-specific responses in T cells is critical to demonstrate efficacy of a T cell-based therapy and to investigate possible side effects".
- Thomas Holberg Blicher, PhD, Senior Research Scientist, Immudex
"MHC Dextramer® are very helpful for us to label cells from immunization experiments to do target-specific cell sorting during the screening process".
- Scientist, Pharmaceutical Company