MHC Multimer Proficiency Panel

In collaboration with CIC (the US Cancer Immuno-therapy Consortium of the CRI) and CIMT (the European Association for Cancer Immunotherapy), Immudex offers Proficiency Panels as a non-profit service to help researchers and clinicians worldwide evaluate and compare their immune monitoring performance with MHC Multimers.

Using laboratory-specific protocols, antibodies, and flow cytometry, participants determine the number of antigen-specific T cells in provided PBMC samples using MHC multimers and receive a report comparing the results from all participating laboratories.

What You Receive

PBMC samples: identical for all participants*
If requested, MHC Dextramer® reagents free of charge (only pay shipping fees)
Assay instructions

What You Measure

Total number of CD8+ T cells in samples
Number of MHC multimer+ CD8+ T cells in samples
Percent of total CD8+ T cells that are MHC multimer+

MHC Multimer Proficiency Panel – Step-by-Step


Register PBMCs

MHC Dextramer® if requested

Assay instructions
Use your own protocol to analyze PBMC samples according to the instructions Report your results back to Immudex Get a report with all participants' performance
Registration opens Autumn 2022

Proficiency Performance 2021

In the MHC Multimer Proficiency Panel 2021, all laboratories received identical PBMC samples for identification of antigen-specific T-cells using MHC multimers, and results were collated to assess the relative accuracy of results across the different laboratories. 13 out of 19 participants (68,4%) had a relative accuracy between 0.66 – 1.5 and were considered to be in “the average range” (dark blue columns).

Learn more in the MHC Multimer Proficiency Panel Report 2021



*Immudex conducts quality control of the PBMC samples before these are shipped to participants.

Participation Fees

Academia and Non-profit Organizations 1400 EUR / 1600 USD
Zero-revenue biotech companies 1850 EUR / 2100 USD
Positive-revenue biotech companies 2450 EUR / 2800 USD
Pharmaceutical companies and CROs 2750 EUR / 3150 USD


Registration For 2022 MHC Multimer Proficiency Panel

Registration for the MHC Multimer Proficiency Panel 2022 opens in Autumn 2022. Contact us at if you’d like to be informed when registration opens.

If you have any questions about the MHC Multimer Proficiency Panel, please write to us at