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MHC Multimer Proficiency Panel

MHC Multimer Reagents?

Laboratories around the world are invited to participate in Immudex' annual MHC Multimer Proficiency Panel.

In the panel, participants get a chance to assess their proficiency in enumerating antigen-specific CD8+ T cells in the provided PBMC samples, using MHC multimer reagents and flow cytometry.

All participants receive identical PBMC samples which they analyze, using their own laboratory-specific protocols. Participants can use their own type of MHC multimer reagents, or they can receive MHC Dextramer® reagents free of charge. After analysis, participants report their data to Immudex, and a report is combined with results and performance from all participants. The participants’ names and affiliations are kept anonymous.

MHC Multimer Proficiency Panel Step-by-step

Sign Up	Receive Samples	Analyze Samples	Upload Data	Receive Report

Register	PBMCs MHC Dextramer® if requested Assay instructions	Use your own protocol to analyze PBMC samples according to the instructions	Report your results back to Immudex	Get a report with all participants' performance
Registration end October 15, 2020	October- November 2020	October - December 2020	Submission closes December 20, 2020	February 2021

Why Participate?

To confirm your capability of performing reliable MHC multimer assays
To compare your performance with peers in the T-cell immune monitoring field
To ensure alignment with your collaborators (e.g. in multicenter trials)
To increase credibility towards your sponsors and regulatory agencies
To identify staff that may require further training and thereby obtain more consistent working practices in your laboratory

Acknowledgement

CTL provides PBMC samples at a reduced price. Immudex conducts quality control of the PBMC samples and MHC Dextramer reagents before these are shipped to the participants.