Get in Touch with our Immune Monitoring Experts
Isolate, analyze, and track B cells:
- Tailored B cell detection: Easily load biotinylated spike fragments or other molecules onto Klickmer® reagents for the sensitive detection of antigen-specific B cells in disease and recovery, designing vaccines, and monitoring long-term memory immunity.
- Exceptional avidity: Klickmer® reagents build on Dextramer® Technology to offer unmatched avidity in binding rare and low-affinity B cell subsets.
- Versatile and sensitive detection: With multiple fluorochrome options, including BV421, FITC, PE, and APC, Klickmer® enables dual staining for minimized background, leading to sensitive and reliable detection.
- Simple workflow: Klickmer® reagents are used to isolate SARS-CoV-2-specific B cells from PBMCs without stimulation, enrichment, or expansion steps.
- Multiplexed insights: Use DNA-barcoded dCODE Klickmer® reagents to link multiple B cell specificities with BCR sequence, surface marker, and gene expression information.
B cells play a role in disease progression, defense against new infections, and immune memory for future assaults. Vaccines leverage these features and thus, in a world facing the possibility of global pandemics, understanding B cell phenotypes, kinetics, durability, and resilience to viral variants is essential.
Our Klickmer® reagents can be loaded with recombinant SARS-CoV-2 proteins to detect and characterize how B cell populations of different specificities respond to COVID-19 infection and vaccines. With a flexible Dextramer® backbone displaying multiple antigens and multiple fluorophores, Klickmer® reagents detect even low-affinity and rare cell subsets. Thus, B cell abundance and phenotype can be monitored long-term as part of vaccine development and evaluation programs.
"I have already recommended Immudex reagents to current and former colleagues because I am satisfied with the quality of the products and the customer support"
- Scientist, Pharmaceutical Company
BV421 is equivalent to Brilliant Violet™ 421, which is a trademark or registered trademark of Becton, Dickinson and Company or its affiliates, and is used under license. Powered by BD Innovation.