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Isolate, analyze, and track B cells:
- Tailored B cell detection: Easily load biotinylated spike fragments or other molecules onto Klickmer® reagents for the sensitive detection of antigen-specific B cells.
- Exceptional avidity: Klickmer® reagents build on Dextramer® Technology to offer unmatched avidity in binding rare and low-affinity B cell subsets.
- Simple workflow: Klickmer® reagents are used to isolate SARS-CoV-2-specific B cells from PBMCs without stimulation, enrichment, or expansion steps.
- Multiplexed insights: Use DNA-barcoded dCODE Klickmer® reagents to link multiple B cell specificities with BCR sequence, surface marker, and gene expression information.
- Versatile applications: The consistent performance of Klickmer® reagents is ideal for detecting B cells in disease and recovery, designing vaccines, and monitoring long-term memory immunity.
B cells play a role in disease progression, defense against new infections, and immune memory for future assaults. Vaccines leverage these features and thus, in a world facing the possibility of global pandemics, understanding B cell phenotypes, kinetics, durability, and resilience to viral variants is essential.
Our Klickmer® reagents can be loaded with recombinant SARS-CoV-2 proteins to detect and characterize how B cell populations of different specificities respond to COVID-19 infection and vaccines. With a flexible Dextramer® backbone displaying multiple antigens and multiple fluorophores, Klickmer® reagents detect even low-affinity and rare cell subsets. Thus, B cell abundance and phenotype can be monitored long-term as part of vaccine development and evaluation programs.
"I have already recommended Immudex reagents to current and former colleagues because I am satisfied with the quality of the products and the customer support"
- Scientist, Pharmaceutical Company