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- In-depth research tools: Use SARS-CoV-2 Dextramer® reagents designed for reliable detection of antigen-specific T cells by in situ staining, flow cytometry, or single-cell multi-omics.
- High sensitivity, strong signal: Dextramer® reagents carry numerous peptide-MHC complexes and fluorophores to promote longer binding times, enhance avidity, and boost signal-to-noise ratio.
- Capture low-affinity T cells: Dextramer® reagents identify rare and low-affinity CD4+ and CD8+ T cells that may go undetected by conventional multimers.
- Ready-to-use panels: Choose pre-defined SARS-CoV-2 Dextramer® Panels targeting an extensive array of validated Spike and Non-Spike epitopes. Alternatively, select your own custom panel.
The SARS-CoV-2 pandemic put understanding immunity center-stage to better equip humanity for disease outbreaks. That knowledge requires grasping T cell phenotypes, kinetics, durability and ultimately exhaustion in response to infection or vaccination. Our SARS-CoV-2 Dextramer® reagents leverage the heightened avidity of Dextramer® Technology to detect and differentiate T cell populations in COVID-19.
Uniform in quality and performance, the spectrum of reagents – from panels to multimers and monomers – identify and characterize antigen-specific CD4+ and CD8+ T cells in blood samples and enable single-cell multi-omic analysis of TCR recognition, TCR sequencing, and gene expression. With SARS-CoV-2 Dextramer® reagents, researchers can evaluate vaccine candidates, explore long-term immunity to COVID-19, predict patients at risk, and even prepare for the next pandemic.
Delve deeper into COVID-19 immunity
"MHC Dextramer® are very helpful for us to label cells from immunization experiments to do target-specific cell sorting during the screening process."
- Scientist, Pharmaceutical Company