Get in Touch with our Immune Monitoring Experts
Advance novel CAR cell therapies with optimal CAR Dextramer® reagents:
- High-avidity multimer technology: The Dextramer® backbone ensures high-avidity, multivalent binding, resulting in heightened sensitivity and superior staining brightness, especially for lowly expressed CAR cells.
- Functional detection: In addition to detection, CAR Dextramer® reagents provide valuable information about the proper folding and functionality of the engineered receptor.
- Broad applicability: CAR Dextramer® bypasses scFv limitations like FMC63-only antibodies and can be adapted to detect diverse CAR-T cell constructs, including bivalent or gated CARs.
- Rapid staining protocol: Strong detection in half the time! With minimal wash steps, our protocol eases your workflow and minimizes handling of your cell samples.
- Simultaneous phenotyping: Detect your CAR cells alongside key surface markers such as CCR7 and CD45, for efficient phenotyping.
Accurate detection of CAR cells is pivotal to their development and translation. However, as CAR therapies become more diverse, reagent flexibility to detect novel CAR constructs and their precise characterization becomes paramount. This is where existing staining reagents are limited.
CAR Dextramer® reagents stand out as a high-avidity multimer technology with exceptional sensitivity that can be loaded with a concept-specific antigen. With a dextran backbone, CAR Dextramer® reagents bind CAR cells multivalently, enhancing sensitivity. Being antigen-based, CAR Dextramer® confirms not only the presence of the CAR on the surface of transduced cells but also their binding of the target antigen - a game-changer for CAR cell analysis.
Read the Blog: “Avidity can make all the difference in detecting CAR-engineered cells”.
"We recommend direct detection of the CAR to determine the % of CAR-positive cells."
- FDA. Draft Guidance for Industry:
Considerations for the development of CAR T Cell Products 03/2022
"I have already recommended Immudex reagents to current and former colleagues because I am satisfied with the quality of the products and the customer support."
- Scientist, Pharmaceutical Company