dCODE Dextramer® (RiO)

Combine Antigen-specificity With Multi-omics Analysis

dCODE Dextramer® (RiO) reagents are DNA barcoded MHC Dextramer® products
designed to be compatible with BD RhapsodyTM Single-Cell Analysis System


Determine T-cell antigen-specificity at single-cell resolution, providing simultaneous information on gene expression and surface markers expression.

In this example, dCODE Dextramer® (RiO) and BD RhapsodyTM Single-Cell Analysis System were used to detect disease-specific CD4+ T cells within thousands of PBMC and to obtain their gene expression profiling at the single-cell level.

Read the Case Study

dCODE Dextramer® (RiO) identified EBV-positive T cells in a PBMC sample (left). The negative control dCODE Dextramer® did not detect any specific cells (right).

Perform simultaneous analysis of antigen specificity, transcriptomic profile, and surface protein expression.

  • High-avidity binding to T-cell receptors thanks to multiple MHC-peptide complexes
  • Massive multiplexing screening thanks to the unique barcode for each MHC-peptide specificity
  • Enrichment of low-frequency cells thanks to PE fluorochromes
  • Multiparametric analysis with BD RhapsodyTM Single-Cell Analysis System

Get the most out of your sample

Combine dCODE® Technology with BD's multi-omics solutions and obtain a full immunological profiling in just one workflow

dCODE Dextramer® (RiO) products


  • MHC I dCODE Dextramer® (RiO) for the detection of CD8+ antigen-specific T cells. See available MHC alleles
  • MHC II dCODE Dextramer® (RiO) for the detection of CD4+ antigen-specific T cells. See available MHC alleles
  • dCODE® Klickmer to create personalized dCODE Dextramer® (RiO) by loading your choice of biotinylated molecules (for B-cell research and much more). Read more about dCODE® Klickmer

     If you want to hear more about our products, please contact customer@immudex.com


Order dCODE Dextramer® (RiO)


dCODE Dextramer® (RiO) is now available in Europe and will soon be available in the rest of the world. 
dCODE Dextramer® (RiO) is available as single reagent or in panels. Discover dCODE Dextramer® grades and test sizes

To order dCODE Dextramer® (RiO) in Europe, please send an e-mail to ordering@immudex.com specifying: 

  • The dCODE Dextramer® grade, Gold or Explore
  • Your choice of MHC-peptide combinations. See our list of available MHC alleles
  • Test size
  • If not otherwise specified, the reagents will be assigned random barcodes. In case you require specific barcodes to avoid overlapping with previous orders, please mention it in your order.

dCODE Dextramer® (RiO) Package Insert

dCODE Dextramer® (RiO) Library Prep Protocol

dCODE Dextramer® (RiO) Product Flyer

dCODE Dextramer® (Rio) Case Study

For research use only. Not for use in diagnostic or therapeutic procedures.
Immudex is the sole manufacturer and provider of dCODE Dextramer® (RiO) reagents, and support related to these products is through Immudex. ​​